The big brain am winning again! I am the greetest! Now, I am leaving Earth for no raisin.
EDIT: After reading your replies, it occurred to me that too much of my everyday speech is made up of lines from the show. Maybe that’s why everyone thinks I’m weird.
The rest of aren’t normal, and that’s what makes us great! … So, Leela, don’t want to be like us? Or do you want to be like Adlai, with no severe mental or social problems whatsoever?
Second EDIT: I didn’t expect so many responses, but I’ve just been reading them all and giggling to myself. Thank you everyone I really needed this. Keep em coming!
Not exactly an iconic line, but I love the delivery:
"Have you heard of the Monks of Deshuba?"
Fry: "I've... not heard of them."
Futurama's great for nerdy science gags, social satire, and pop culture spoofs, but its best jokes are always uniquely stupid twists of language like this.