this post was submitted on 17 Jul 2023
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Science

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[–] Dee_Imaginarium@beehaw.org 9 points 1 year ago* (last edited 1 year ago) (2 children)

I wish there were some link to the study in the article, I tried to find it in the original Financial Times article but I got paywalled. This is really awesome though, I hope further research is shown because I'd love to hear more about how this differs from the previous methods of addressing Alzheimer's.

I guess

Both lecanemab and donanemab are based on antibodies against amyloid, one of the toxic proteins that build up in the brain as Alzheimer’s proceeds, but they worked at different stages of the process, Oakley said. Lecanemab targets amyloid as it begins to form fibers in the brain while donanemab is active at a later stage, when the fibers have clumped together into larger accumulations of plaque.

Is as close as we're getting for now haha

Edit: TheOakTree found the study for those who want to read more!

Direct link to study.

[–] TheOakTree@beehaw.org 8 points 1 year ago* (last edited 1 year ago) (1 children)

https://jamanetwork.com/journals/jama/fullarticle/2807533

May or may not be exactly what you were looking for, did not confirm lol

[–] Dee_Imaginarium@beehaw.org 5 points 1 year ago (1 children)

From the Ars Article:

The donanemab trial involved 1,736 participants

From your link:

Findings In this randomized clinical trial that included 1736 participants with early symptomatic Alzheimer disease and...

I would be VERY surprised if this wasn't the study in question 😂

Thank you for finding that! I'll read that over more when I get some time later!

[–] TheOakTree@beehaw.org 4 points 1 year ago

Now imagine if it were coincidence...

Thankfully it's not. Happy to see that alzheimer research is getting more interest though, it's a scary condition.

[–] FlowVoid@midwest.social 4 points 1 year ago (1 children)

The article mentions the donanemab study was published in JAMA. A little bit of Googling retrieved this:

https://jamanetwork.com/journals/jama/fullarticle/2807533

[–] Dee_Imaginarium@beehaw.org 1 points 1 year ago* (last edited 1 year ago) (1 children)

Yup, you're an hour late to that convo haha

I'll edit my original comment so others see that though.

[–] FlowVoid@midwest.social 1 points 1 year ago (1 children)

Weird, that comment definitely wasn't visible to me when I replied. Must be the magic of federation...

[–] Dee_Imaginarium@beehaw.org 2 points 1 year ago

Oh yeah, because you're both from different instances. I didn't think about that, we're all still learning lol

[–] Gaywallet@beehaw.org 5 points 1 year ago

extremely promising! awesome to see

[–] photonic_sorcerer@lemmy.dbzer0.com 4 points 1 year ago (1 children)

Finally some good fucking news. Wish we had the article, though.

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