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I think the main benefit of drugs is making new states of mind known, so they can later be sought organically.
One of my teachers said it’s like climbing a mountain in a rainstorm, and then suddenly there’s a flash of lightning and you see the whole mountain for a moment.
SSRIs and other antidepressants are good for people who’ve forgotten what it’s like to be at ease, who’ve been in the shit for so long that they don’t have any mental connection to a world outside of the shit any longer.
Then you just force the serotonin activity up, and this reintroduces the person to a better life. They can stay there for a while and become acquainted with it. It can give them a reason to try.