Initially, THC boosted brain metabolism and synaptic protein levels, indicative of heightened cognitive processes. Subsequently, it shifted towards reducing metabolic activities in the body akin to the effects seen with caloric restriction or intensive exercise, known for their anti-aging benefits.

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[–] weariedfae@lemmy.world 6 points 2 months ago (3 children)

I wonder if micro dosing can give the same effects? I am a control freak and don't like to be high but worry about cognitive decline. Especially since I got long covid and fucked up my olfactory system. Brain damage sucks.

[–] Angry_Autist@lemmy.world 3 points 2 months ago

Most days I microdose by diluting extract in glycerine, roughly 1/4 of a joint paced out thru the day.

Works wonders for my EDS, and I don't feel high at all and have a ton more executive control.

Can't really reply on the cognitive decline but I'm pushing 50 and still in the top .5%

Long Covid did drop me a bit tho, but I guess when you start with a straight eight, losing two cylinders isn't so bad.

[–] southsamurai@sh.itjust.works 2 points 2 months ago

The actual paper published is about smaller doses.

[–] LustyArgonianMana@lemmy.world 1 points 2 months ago* (last edited 2 months ago)

It would be better to microdose lithium if you really don't want to be high imo. 5-20mg range, can be intermittent (doses for bipolar are in the 100mg range and up). There's already lithium in some water supplies and in foods like potatoes, so a small amount in a microdose normally doesn't affect anyone negatively.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227915/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324565/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10994667/#:~:text=In%20the%20present%20work%2C%20long,aging%20process%20of%20SAMP%2D8.

I will say over time your body will adjust to cannabis so if you microdose at night consistently before bed, you'll just sleep it off anyway and eventually it won't even get you high anymore.