Factorio

1. Rush sciences to make myself turboman-roboport.
2. Never craft anything by hand after the first hour or two.
3. Create small but modular/pasteable designs.. also just make bad designs that work 'good enough' and move on to the next task.
4. Before turboman, never walk, I add a commuter train that goes to every main work/supply destination.

I don't walk unless I have to, and I modify my base to remove any tedious walking I find myself doing.