Honestly, I used to use self deprecating humor a lot, but it does eat away at your own self esteem if your repeat it enough and it can make others feel inadequate as well. One of the qualities I've admired the most in others and that I try to emulate is unapologetically taking responsibility for mistakes or shortcomings. "Wow, I should have caught that. That was silly of me, I'll do better" is a lot better than something like "now I see why I had to ride the short bus" or "I'm such an idiot" .... At the end of the day, no one is perfect, and we shouldn't hold ourselves or others to unachievable standards. We should just always strive to do better.