While I am quite worried with the change. Honestly, if there's a will there's a way, especially for a site as big as youtube with a huge target on their back.

People would find a way to get around the whole ad-block thing, especially with 3rd party site scraping client like Newpipe (or its equivalent on pc) or Invidious (sure, they got a bit of dmca going on, but there will probably be another individual willing to retake the mantle similar to revanced when vanced were shut down).