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this post was submitted on 03 Sep 2023
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You Should Know
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These three drugs work in completely different ways, by the way.
Disulfiram gets the patient to stop drinking alcohol by causing the body to accumulate poisonous acetaldehyde — causing drunkenness to rapidly become a hangover.
Naltrexone is used in the Sinclair method, and works by suppressing the positive feelings (psychological reward) of drinking. Notably, Sinclair method patients are instructed to take naltrexone and then drink alcohol; the lack of reward trains the brain to not think of alcohol as pleasant anymore.
Acamprosate counteracts the downregulation of GABA receptors, making it less unpleasant to go without drinking.
Yes, Disulifram is the oldest of these, been around many years, and some chronic alcoholics just drink over it and power through the hangover
Naltrexone is the one I have heard most positive things about, never even heard of Acamprosate before.
Unfortunately when I was in a relationship with an alcoholic some years back Disulifiram was the only thing doctors here were even aware of.
Baclofen has also shown promise as adjuvant to naltrexone, I believe.
Hows he doing currently?