That's not the sort of community I thought I'd be commenting on, but here we are.
The genre is often referred to as "Rogue-Lite". Not quite a Rogue Like but bears the same hallmarks:

• run based
• often low HP
• often generative level design
• items change the run

So if you want more like this I'll just dump my favourites:

• Enter the Gungeon - Bit more bullet-hellish than Isaac, but I'd say one of the genre MUST plays. One of the best.
• Hades - critically acclaimed hack and slash take on the genre. looks sweet as hell too
• Rogue Legacy 1 & 2 - Also two of the OGs. bit more platformery in it's movement but same idea
• Risk of Rain 2 - Same idea... but 3D 3rd person shooter / hero action genre mashup. Probably in my top 5 games ever made. Play. it.
  RoR1 is also a gem but a bit harder to get into. 2D sidescroller. But there's sort of a overhauled remake sequel coming soon, so might as well wait for that.

Before this gets too long, if you want something more bite sized and are open for slightly different gameplay loops, check out Vampire Survivors and the likes. 20 Minutes Till Dawn, Brotato...